1993-1997Department of Modern Applied Physics, Tsinghua University B.S.
1997-1999 Start Computer Company Engineer
2000-2003Department of Biological Science and Biotechnology, Tsinghua University M.S.
2004-2009 Department of Chemistry, Purdue University Ph.D.
2010-2013 Department of Chemistry, Purdue University Postdoc.
2013-2016 University of Michigan/Duke University Postdoc.
2016-Present School of Life Sciences, Tsinghua University Principal Investigator
主要科研领域与方向Our primary research interests are focused on characterizing structure and dynamics
of non-coding RNAs and intrinsically disordered proteins using solution NMR
spectroscopy and computational approaches such as MD simulations. We aim to
develop novel NMR techniques, labeling methods, and computational tools to study
three-dimensional structure and conformational switch of large non-coding RNAs
and ribonucleoproteins, which pose a significant challenge to existing methods.
We are also interested in reconstructing conformational motion of highly flexible
biomolecules, as well as ensemble-based virtual drug screening.
代表性论文 1. Xue Y, Gracia B, Herschlag D, Russell R, Al-Hashimi HM. (2016) Visualizing formation of an RNA folding intermediate through a fast highly modular secondary structure switch. Nature Communications, 7:11768. 2. Ren A, Xue Y, Peselis A, Serganov A, Al-Hashimi HM, Patel DJ. (2015) Structural and dynamic basis for low-affinity, high-selectivity binding of L-glutamine by the glutamine riboswitch. Cell Reports, 13(9):1800-13. 3. Ma P, Xue Y, Coquelle N, Haller JD, Yuwen T, Ayala I, Mikhailovskii O, Willbold D, Colletier JP, Skrynnikov NR, Schanda P. (2015) Observing the overall rocking motion of a protein in a crystal. Nature Communications, 6:8361. 4. Xue Y, Yuwen T, Zhu F, Skrynnikov NR. (2014) Role of electrostatic interactions in binding of peptides and intrinsically disordered proteins to their folded targets. 1. NMR and MD characterization of the complex between the c-Crk N-SH3 domain and the peptide Sos. Biochemistry, 53 (41): 6473–6495. 5. Xue Y, Ward JM, Yuwen T, Podkorytov IS, Skrynnikov NR. (2012) Microsecond time-scale conformational exchange in proteins: using long molecular dynamics trajectory to simulate NMR relaxation dispersion data. J Am Chem Soc, 134 (5):2555–2562. 6. Xue Y, Skrynnikov NR. (2011) Motion of a disordered polypeptide chain as studied by paramagnetic relaxation enhancements, 15N relaxation, and molecular dynamics simulations: how fast is segmental diffusion in denatured ubiquitin? J Am Chem Soc, 133 (37): 14614–14628.
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